2019年湖北省武汉市儿童呼吸道合胞病毒感染临床特征及流行病学分析

黄珮琪; 陆小霞; 陈和斌; 杜青; 李颖; 杜慧; 雷小丽

doi:10.3784/j.issn.1003-9961.2020.11.007

引用本文: 黄珮琪, 陆小霞, 陈和斌, 杜青, 李颖, 杜慧, 雷小丽. 2019年湖北省武汉市儿童呼吸道合胞病毒感染临床特征及流行病学分析[J]. 疾病监测. DOI: 10.3784/j.issn.1003-9961.2020.11.007 shu

Citation: Peiqi Huang, Xiaoxia Lu, Hebin Chen, Qing Du, Ying Li, Hui Du and Xiaoli Lei. Clinical and epidemiological characteristics of respiratory syncytial virus infection in children in Wuhan, Hubei, 2019[J]. Disease Surveillance. DOI: 10.3784/j.issn.1003-9961.2020.11.007 shu

2019年湖北省武汉市儿童呼吸道合胞病毒感染临床特征及流行病学分析

黄珮琪 ^{1

,} ,
陆小霞 ^{2

,

,} ,
陈和斌 ² ,
杜青 ² ,
李颖 ² ,
杜慧 ² ,
雷小丽 ²

1.
江汉大学，湖北武汉 430056
2.
武汉儿童医院，湖北武汉 430015

作者简介: 黄珮琪，女，湖北省武汉市人，硕士研究生，主要从事儿童呼吸道感染性疾病相关研究，Email：413111721@qq.com;

通信作者: 陆小霞, lusi74@163.com

摘要: 目的分析2019年湖北省武汉市呼吸道合胞病毒（RSV）引起儿童急性呼吸道感染（ARTI）的流行病学特征，总结其临床特点。方法收集2019年因ARTI在武汉儿童医院治疗的患儿鼻咽拭子标本。采用直接免疫荧光法检测样本中的RSV，根据临床资料进行流行病学分析。结果2019年武汉市ARTI患儿中RSV阳性率为8.41%，不同年龄段患儿检出率差异有统计学意义（P<0.05），且RSV的检出率随患儿年龄增加而逐渐降低。男性患儿中的检出率高于女性患儿（P<0.05）。 RSV在1 — 2、12月检出率最高，在5 — 7月检出率最低。患儿临床表现主要为咳嗽、发热、喘息。部分患儿可出现其他并发症，如肝功能异常、癫痫、心律失常、中耳炎等。 RSV与其他呼吸道病毒的混合感染率为2.81%，主要为副流感病毒3型及腺病毒。结论RSV是武汉市儿童ARTI的常见病原，流行时间为12月至次年2月，患儿年龄越小越容易被感染。 RSV易与副流感病毒3型及腺病毒发生混合感染。

关键词:

English

Clinical and epidemiological characteristics of respiratory syncytial virus infection in children in Wuhan, Hubei, 2019

Peiqi Huang ^{1

,} ,
Xiaoxia Lu ^{2

,

,} ,
Hebin Chen ² ,
Qing Du ² ,
Ying Li ² ,
Hui Du ² ,
Xiaoli Lei ²

1.
Jianghan University, Wuhan 430056, Hubei, China
2.
Wuhan Children's Hospital, Wuhan 430015, Hubei, China

Corresponding author: Xiaoxia Lu, lusi74@163.com

Received Date: 2020-08-28
Available Online: 2020-11-30

Abstract: ObjectiveTo understand the epidemiological characteristics and clinical characteristics of acute respiratory tract infection caused by respiratory syncytial virus (RSV) in children in Wuhan, Hubei province, in 2019.MethodsThe nasopharyngeal swabs of children admitted to Wuhan Children's Hospital due to acute respiratory infection in 2019 were collected. RSV positive children were detected by direct immunofluorescence method. Their clinical and epidemiological data were analyzed.ResultsIn 2019, the positive rate of RSV in children with acute respiratory infection in Wuhan was 8.41%. There was a significant difference among children in different age groups, and the detection rate of RSV decreased gradually with age. The detection rate in boys was higher than that in girls (P<0.05). The highest detection rate of RSV was during January, February, December, and the lowest was during May - July. The main clinical manifestations were cough, fever and wheezing. Some children had other complications, such as abnormal liver function, epilepsy, arrhythmia, otitis media and so on. The incidence rate of co-infection of RSV and other respiratory viruses was 2.81%, mainly parainfluenza virus type 3 and adenovirus.ConclusionRSV is a common pathogen of acute respiratory tract infection in children in Wuhan. The infection mainly occurs during December - February. Younger children are more likely to be infected. The co-infection of RSV with parainfluenza virus type 3 and adenovirus is prone to occur.

Key words:

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图 1 2019年不同月份武汉市急性呼吸道感染住院儿童呼吸道合胞病毒检出情况

Figure 1. Detection of RSV in hospitalized children with acute respiratory tract infection in different months in Wuhan, 2019

下载: 全尺寸图片幻灯片

表 1 1 315例呼吸道合胞病毒阳性病例的性别和年龄分布

Table 1. Gender and age distribution of 1 315 children with RSV infection

特征	检测病例数（例）	RSV阳性数（例）	检出率（%）	χ²值	P值
性别				9.180	0.002
男性	9 675	865	8.94
女性	5 956	450	7.56
年龄组（岁）				521.712	<0.001
0～	8 198	1 079	13.16
1～	6 069	231	3.81
6～11	1 364	5	0.37
合计	15 631	1 315	8.41
注：RSV. 呼吸道合胞病毒